High quality data revealing the pharmaco- and toxicokinetic properties of a biotherapeutic are essential to making confident decisions throughout the drug development workflow.
PK/TK assays are among the most common applications performed on the Gyros platform. During preclinical studies, entire kinetic profiles can be generated from a single animal. Multiple analytes can be assayed in limited sample volumes.
Save time and samples
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Generate profiles in days - monitor multiple analytes in a single animal |
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More data points, fewer animals - minimize biological variation in preclinical trials |
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Fast development - new assays can be running within days |
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Fast turnaround - automation improves throughput, speeds up assay validation |
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Fewer dilutions - broad dynamic range and reduced matrix effects |
Data examples
One PK:one mouse at Astra Zeneca
Use samples more effectively - multiple analytes in nanoliter volumes
Working at nanoliter scale ensures more effective use of small sample volumes. For example, when using small animal models, more data points can be generated from a single bleed and errors due to biological variations minimized.
A simple calculation shows the effect on the number of samples required as demand for more analyte assays per subject increases:
Assuming a typical requirement of 10 µl per analyte for a conventional technique, the number of animals required increases significantly. Gyrolab Bioaffy 200 enables up to 20 analytes to be assayed using the same number of samples as would be required to assay only 3 analytes using conventional techniques.
Transfer easily between labs or into regulated environments
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Template methods simplify outsourcing and assay transfer |
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Gyrolab software is 21 CFR Part 11 compliant and regulatory support is available |